Coumarins and derivatives
Medchemexpress LLC 3-nitro-2H-1-benzopyran-2-one | 28448-04-6 | 100.0% | 191.14 | 100 MG
3-Nitrocoumarin is an inhibitor for phospholipase C (PLC) that blocks the generation of inositol triphosphate (IP3), thereby affecting the calcium signaling pathway. It is intended for research use only.
- Inhibits phospholipase C.
- Blocks the generation of inositol triphosphate (IP3).
- Affects the calcium signaling pathway.
- Inhibits glucose-induced increase of intracellular calcium ions in yeast strain WPY260.
- Inhibits PLC in Neurospora crassa with an IC50 of 10 μg/mL.
- Inhibits the growth of N. crassa and causes morphological changes of apical hyperbranching in hyphae.
Apexbio Technology LLC Palomid 529 914913-88-5 10mg
Palomid 529 (CAS 914913-88-5) is a small-molecule inhibitor of the PI3K/Akt/mTOR signaling pathway targeting both TORC1 and TORC2 complexes It exhibits potent anti-proliferative activity in the NCI-60 cell line panel with GI50 values below 35 M In endothelial cell assays Palomid 529 inhibits VEGF- and bFGF-induced proliferation with IC50 values of 20 nM and 30 nM respectively The PI3K/Akt/mTOR pathway is implicated in tumor cell survival proliferation angiogenesis and resistance to apoptosis Palomid 529 has also demonstrated the ability to suppress radiation-induced expression of Id-1 VEGF MMP-2 and MMP-9 expanding its utility in studies of cancer biology and radiotherapy sensitization
eMolecules 58336-35-9 | Medchem Express | Coumarin 6H | 50mg | 769193272 | HY-121930 | MFCD00227485 | 241.29 | C15H15NO2
Medchem Express | Coumarin 6H | 50mg | 769193272 | HY-121930 | 58336-35-9 | MFCD00227485 | 241.290 | C15H15NO2
Medchemexpress LLC 4H-1-Benzopyran-4-one, 7-[[6-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]oxy]-5-hydroxy-2-(4-methoxyphenyl)- | 480-36-4 | 592.55 | 20 MG
Linarin (Buddleoside) is an orally active and selective inhibitor of acetylcholinesterase (AChE). It exhibits various activities including anti-inflammatory, antioxidant, sleep aid and sedation, bone differentiation, anti-tumor, antibacterial, and antiviral properties. Linarin can be utilized in the study of diseases affecting the nervous system, osteoporosis, and cancer.
- Orally active and selective inhibitor of acetylcholinesterase (AChE).
- Anti-inflammatory properties.
- Antioxidant properties.
- Sleep aid and sedation.
- Promotes bone differentiation.
- Anti-tumor activity.
- Antibacterial properties.
- Antiviral properties.
- Useful for studying diseases such as those of the nervous system, osteoporosis, and cancer.
Medchemexpress LLC MTX-531 | 2791417-66-6 | 99.9% | 453.94 | 5 MG
MTX-531 is an oral drug that inhibits EGFR and PI3K isoforms (PI3Kα, PI3Kβ, PI3Kγ, and PI3Kδ). It has anti-tumor effects and acts as a weak agonist of PPARγ, which helps mitigate hyperglycemia often induced by PI3K inhibitors. It shows excellent tolerance in mice and has demonstrated concentration-dependent inhibitory effects on EGFR, P13K, and mTOR in CAL-33 cells.
- Inhibits EGFR and PI3K isoforms
- Acts as a weak agonist of PPARγ, alleviating PI3K inhibitor-induced hyperglycemia
- Demonstrates anti-tumor activity in various models
- Administered orally
- Shows excellent tolerance in mice
Medchemexpress LLC Coumarin-3-carboxylic acid | 531-81-7 | MFCD00006852 | 99.9% | 190.15 g/mol | C10H6O4 | 25 G
Coumarin-3-carboxylic acid is a small-molecule fluorescent probe (C10H6O4, MW 190.15 g/mol) used to detect hydroxyl radicals and study oxidative stress in analytical and biochemical research. It is provided in high-purity solid form and as a DMSO solution for convenient use in assays and photophysical measurements.
- High purity suitable for analytical and preparative work.
- Strong fluorescence signal for sensitive radical detection.
- Available in multiple package sizes and solution format.
- Documented spectral and chromatographic data for quality assurance.
- Applicable to in vitro assays and photophysical studies.
Medchemexpress LLC Coumarin 6H | 58336-35-9 | 99.6% | 1 ML
Coumarin 6H is a coumarin-family laser dye supplied as a high-purity solid or as a 10 mM solution in dimethyl sulfoxide (DMSO). It exhibits strong fluorescence that can be enhanced through hydrogen-bonding interactions, making it suitable for laser dye and fluorescence applications.
- Available as 10 mM solution in DMSO or as solid quantities (50 mg-1 g).
- High purity, typically 99.6%.
- Molecular formula C15H15NO2 and molecular weight 241.29 g·mol^-1.
- Fluorescence emission enhanced by hydrogen bonding interactions.
- Soluble in common organic solvents such as DMSO.
- Intended for use as a laser dye and fluorescent probe in optical applications.
Selleck Chemical LLC Palomid 529 (P529) S2238-1g
Palomid 529 (P529 SG 00529) inhibits both the mTORC1 and mTORC2 complexes reduces phosphorylation of pAktS473 pGSK3 S9 and pS6 Phase 1
eMolecules 84227-70-3 | (4-Aminomethylbenzyl)diethylamine | MFCD07343995 | 1g
Combi-Blocks | (4-Aminomethylbenzyl)diethylamine | 1g | 117572923 | ST-6479 | 95.000 | 84227-70-3 | MFCD07343995 | 192.306 | C12H20N2
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Medchemexpress LLC 6-Bromocoumarin | 19063-55-9 | 225.04 | 1 G
6-Bromocoumarin is a potential anti-bacterial agent that exhibits affinity for α and β estrogen receptors. It does not inhibit 17β-HSD1 and is intended for research use only.
- Potential anti-bacterial agent
- Exhibits affinity for α and β estrogen receptors
- Does not inhibit 17β-HSD1
- High purity of 98.51%
- White to off-white solid appearance
- Molecular weight of 225.04
Medchemexpress LLC 3-aminochromen-2-one | 1635-31-0 | 99.2% | 161.16 g·mol⁻¹ | C9H7NO2 | 100 MG
3-Aminocoumarin (3-aminochromen-2-one) is a small organic intermediate used in coordination chemistry and materials research. It serves as a ligand precursor for the synthesis of metal complexes and related coordination compounds. Supplied for research use, the compound is offered at high reported purity and in multiple laboratory package sizes.
- Intermediate for synthesis of metal complexes and coordination compounds.
- Acts as a ligand precursor in coordination chemistry.
- High purity suitable for research applications.
- Available in multiple small-scale package sizes for laboratory use.
- Molecular formula C9H7NO2; molecular weight 161.16 g·mol⁻¹.